Volume 3 Supplement 1

Proceedings of the 1st International Workshop on Odor Spaces

Open Access

Correlated glomerular convergence and latency coding of odors in mitral cells

  • Detlev Schild1
Flavour20143(Suppl 1):O12

DOI: 10.1186/2044-7248-3-S1-O12

Published: 16 April 2014

Behavioral responses to olfactory stimuli can happen after less than half a second after stimulus arrival. Given ORN spike rates in the order of 0 to 15 spikes/s it appears unlikely that average spike rates play a major role for the detection of the odor and the bahavioral response to it. We therefore assumed the other extreme, i.e. that the first spike of an odor response of a mitral cells is important for detection and quality coding (which does not exclude other effects). Using activity contrast imaging (ACI, [1]) we could indeed show that the response latency vectors code odor quality with high fidelity [2] in virtually synchronous ensembles of mitral cells [3]. We hypothesize that the first spike of a mitral cell is somehow induced by correlated glomerular input. This view is strengthened by the existence of bifurcations in ORN axons so far seen in Xenopus [4] and mice [5]. Such bifurcations obviously lead to hardwired correlations in an ontogenetical situation where, due to a relatively low number of axons, stimulus-induced, correlated ORN activities are sparse or absent.

Authors’ Affiliations

(1)
University of Göttingen

References

  1. Junek S, Chen T-W, Alevra M, Schild D: Activity correlation imaging: visualizing function and structure of neuronal populations. Biophys J. 2009, 96: 3801-3809.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Junek S, Kludt E, Wolf F, Schild D: Olfactory coding with patterns of response latencies. Neuron. 2010, 67: 872-884.View ArticlePubMedGoogle Scholar
  3. Chen T-W, Lin B-J, Schild D: Odor coding by modules of coherent mitral/tufted cells in the vertebrate olfactory bulb. Proc Natl Acad Sci U S A. 2009, 106: 2401-2406.PubMed CentralView ArticlePubMedGoogle Scholar
  4. Nezlin LP, Schild D: Individual olfactory sensory neurons project into more than one glomerulus in Xenopus laevis tadpole olfactory bulb. J Comp Neurol. 2005, 481: 233-239.View ArticlePubMedGoogle Scholar
  5. Marcucci F, Maier-Balough E, Zou D-J, Firestein S: Exuberant growth and synapse formation of olfactory sensory neuron axonal arborizations. J Comp Neurol. 2011, 519: 3713-3726.View ArticlePubMedGoogle Scholar

Copyright

© Schild; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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