The pleasure of food: underlying brain mechanisms of eating and other pleasures
© Kringelbach; licensee BioMed Central. 2015
Received: 19 December 2014
Accepted: 30 December 2014
Published: 2 March 2015
As all chefs know, great food can have a transformational impact. A great deal of recent research has gone into using the new techniques from molecular gastronomy and gastrophysics to create innovative meals with delicious original textures and flavours. These novel creations have elicited much excitement from food critiques and diners alike. Much stands to be gained if these developments were to be matched by a better understanding of how the pleasure of food comes about in the brain. This review summarises the current state-of-the-art of the science of pleasure and specifically the brain’s fundamental computational principles for eating and the pleasures evoked. It is shown how the study of food has advanced our understanding of the unitary pleasure system that is used for all pleasures. As such, these novel insights may come to serve as a guide for chefs of how to combine science and art in order to maximise pleasure—and perhaps even increase happiness.
KeywordsDinner Gastronomy Brain Pleasure cycle Satiety Satiation Hedonic Pleasure Food Multimodal integration Insula Operculum Orbitofrontal cortex Cingulate cortex Wanting Liking Learning Anhedonia
The novella “Babette’s Feast” by the Danish writer Karen Blixen (writing under her nom du plume of Isak Dinesen) is set in the 1870s, describing an austere religious sect, whose members “…renounced the pleasures of this world, for the earth and all that it held to them was but a kind of illusion, and the true reality was the New Jerusalem toward which they were longing” . Martine and Phillipa are the unmarried daughters of the founder of the religious sect who have a French maid-of-all-work, Babette, appearing from war-torn Paris under mysterious circumstances. Upon her arrival, the pious daughters are anxious to avoid any “… French luxury and extravagance” and therefore at the time explained that they “… were poor and that to them luxurious fare was sinful. Their own food must be as plain as possible”. As it happens, their worries are allayed; and for next 12 years, Babette serves them such that the whole community come to acknowledge her excellence and depend on her quiet gifts. When Babette unexpectedly wins a princely sum of money in the French lottery, they become afraid she may leave them. Accordingly, against their better judgement, the sisters agree that Babette may cook them a special dinner celebrating the 100th anniversary of the sect’s founding father. Unbeknownst to the sisters, Babette used to be a cordon bleu cook who prepares a sumptuous once-in-a-lifetime meal, leaving the guests questioning their lifelong denial of mortal pleasures.
In the novella, this cathartic meal is not described in much detail, following the vow of the devout and taciturn guests “… not to utter a word about the subject”. In contrast, Danish director Gabriel Axel’s Oscar-winning film adaptation tries hard to use visuals to convey the splendour of the dinner but still falls short of conveying the multisensory experience of a fine meal. Blixen is astute in using linguistic sparseness as a plot device, given that language, even that employed by great writers , very often fails to convey the exquisite sensory experiences of food upon which the story hinges. Blixen even feels moved to suggest that it is “… when man has not only altogether forgotten but has firmly renounced all ideas of food and drink that he eats and drinks in the right spirit”. Language for all its powers is powerless when it comes to evoking the food’s sensory routes to pleasure, yet the unity of pleasure is beautifully evoked: “Of what happened later in the evening nothing definite can here be stated. None of the guests later on had any clear remembrance of it. They only knew that the rooms had been filled with a heavenly light as if a number of small halos had blended into one glorious radiance. Taciturn old people received the gift of tongues; ears that for years had been almost deaf were opened to it. Time itself had merged into eternity. Long after midnight the windows of the house shone like gold, and golden song flowed out into the winter air”.
Thus, Babette’s feast becomes a route to intense well-being, and the pleasure is not just about the food but instead about providing unity and transcendence for the virtuous dinner guests who all leave the meal changed, suddenly awake to the potential of earthly pleasures.
For many years, such pleasures have remained mysterious and firmly within the domain of much great art. Yet, the advent of modern neuroscience has started to uncover some of the underlying mechanisms of associated brain changes.
This review describes what is known of the processing of food in scientific terms; from sensory identification of the uni- and multisensory properties of food to the associated prediction, memory and evaluation involved which may give rise to the experience of pleasure. Like all rewards, food depends on processing in interconnected and widespread brain regions to identify and characterise the different sensory properties and their multimodal integration. This processing is detailed in a multilevel model of the constituent processes involved in food intake over time. The focus here, however, is on the fundamental underlying brain mechanisms governing the initiation and termination of a meal leading to pleasure. Overall, the accumulated evidence shows that the pleasure evoked by food is remarkably similar to that of other rewards, suggesting a unitary pleasure system, whether engaging with food, sex, social or higher-order rewards. Food is thus not only highly pleasurable but also an excellent tool for discovering fundamental principles of brain function.
Brain principles of eating
While food clearly is essential to survival, it is the pleasure involved that makes eating worthwhile. While the members of the religious sect in Blixen’s novella may try hard to deny the pursuit of pleasure in its many forms, their well-being is ultimately strongly enhanced as they submit to Babette’s cooking, i.e. to the strong primal drive for pleasure. The evolutionary imperatives of survival and procreation are not possible without the principle of pleasure for the fundamental rewards of food, sex and conspecifics—and as such may well be evolution’s boldest trick . The scientific study of pleasure, hedonia research, is dedicated to searching for the functional neuroanatomy of hedonic processing, taking its name from the ancient Greek for pleasure (ἡδονή; transl. hédoné) derived from the word for “sweet” (ἡδύς, transl. hēdús) .
In the novella, the sect’s initial food asceticism may stem from their religious beliefs but is guided by the basic homeostatic regulation of human eating behaviour , of which animal models have elucidated in great details the many subcortical circuits and molecules shared amongst mammals including humans [6-8]. Yet, as illustrated by the effects of Babette’s Feast, homeostatic processes are not solely responsible for human eating. This hedonic eating is difficult to suppress and is even more poignantly illustrated by the current worldwide obesity pandemic . There is often very little well-being linked to such over-eating, with anhedonia—the lack of pleasure—being a prominent feature of affective disorders. From this public health perspective, it is imperative that we better understand the fundamental pleasure systems such that we find new and more effective ways of re-balancing the system and potentially reducing obesity which is threatening to undermine public health .
Eating can seem simple but at its most basic, human food intake is still rather complex. The procurement of food can be surprisingly difficult in the wide variety of often hostile climates inhabited by humans. Once food is available, the preparation and eating of food are also complex processes, involving a multitude of peripheral and central processes for carefully orchestrated acts requiring significant brain processing. The necessary, sophisticated motivational, emotional and cognitive processing are likely to have been main drivers for the evolution of large primate brains . The brain principles underlying eating have been investigated for a long time in many mammalian species [6,12]. Here, the focus is on the pleasure component of human eating, which over the last decade has started to transform our understanding [13,14].
The dual processes of satiation and satiety are central to the model and to the energy obtained by the associated meals . Terminating eating is complex process, which is encapsulated by satiation , while satiety is the feeling of fullness that persists after eating to suppress further eating. These processes are controlled by a cascade of sensory, cognitive, post-ingestion and post-absorptive signals, beginning with the consumption of a food in a meal and continuing as the food is digested and absorbed.
The multilevel model of food intake describes the changes over time in A) pleasure, B) the levels of hunger, C) satiation/satiety cascade signals, D) origin of signals and signal carriers, E) brain processes, F) behavioural changes including those in the digestive system and G) general modulatory factors (Figure 2). Many of these changes have been described elsewhere, e.g. the mechanisms of the changes after the termination of a meal such as the gut-brain interactions, include signals from receptors in the digestive tract which are sensitive to calorie-rich nutrients (even in the absence of taste receptors) [24,25].
This sensory information about food is coming from receptors in the body, typically the eyes, ears, nose and oral cavity and gets processed in the primary sensory cortices of the brain. The topology of these regions are remarkably similar between people with vision (red) always processed in the back of the brain, audition (dark blue) processed in regions of the temporal cortex, touch (light blue) in somatosensory regions and olfaction (orange) and taste (yellow) in frontal regions (Figure 3B). Importantly, unlike the other senses, olfactory processing is not processed via the thalamus which may explain the hedonic potency of odours . Note that it is important that we are able to identify a food stimulus independently of whether we are hungry or sated, and accordingly, sensory information in primary sensory cortices is remarkably stable and not modulated by motivational state.
The sensory information is further integrated in multisensory areas before it is evaluated for reward value in the pleasure system. Here, the processing depends on prior memories, expectations and state and may give rise to brain activity which gives rise involuntary pleasure-evoked behaviour (such as licking of lips or soft moaning) and, at least in humans, subjective pleasure (Figure 3C).
Neuroscience has started to map the pleasure system in many species. This has been shown to include a number of important regions such as pleasure hotspot regions in subcortical areas of the brain such as the nucleus accumbens and ventral pallidum [28,29]. Manipulations of these regions with opioids have been shown to causally change pleasure-elicited reactions . Other regions involved in pleasure have been found using human neuroimaging in the orbitofrontal, cingulate, medial prefrontal and insular cortices [30-37]. The pleasure system does not act in splendid isolation but is of course embedded within much larger brain networks. We are beginning to understand the metastable nature as well as the topological and functional features of these networks using advances in network science and graph theory together with advanced whole-brain computational models [38,39].
Computational processing principles for eating
Overall, eating has been demonstrated to rely on at least five fundamental processing principles: 1) hunger and attentional processing; 2) motivation-independent discriminative processing of identity and intensity; 3) learning-dependent multisensory representations; 4) reward representations of valence and 5) representations of hedonic experience [12,40]. In the following, these are briefly described.
Hunger and other attentional processing
Typically, changes in ongoing brain activity are driven by changes in the internal or external environment, signalling that the brain needs to start to reallocate resources and change behaviour. This motivational drive for change is strong for food intake, where hunger is a major attentional signal that along with other homeostatic signalling can influence the brain to initiate food-seeking behaviours, typically following the satiety phase from the previous meal. The hunger information comes primarily from gut-brain interactions signalling if the nutrients eaten in the previous meal have yielded the expected amount of energy but a large part is also played by habit (such as regular meal times) and learning, including social interactions which may lead to overeating due to diminished attention towards the food [41,42]. Signals from receptors in the gut and in the circulatory system are vital in initiating eating through conveying messages for the need of nutrients or energy uptake [6,43].
The healthy system is balanced through careful monitoring and learning throughout life. In the presence of sufficient nutrients, healthy adults are able to maintain a stable body weight by careful management of nutrient uptake, energy needs and the balance with energy expenditure . In animal models, this homeostatic component has been shown to relate to activity in hypothalamic circuits including the arcuate nucleus [6,43]. Hedonic influences beyond homeostasis can lead to malfunction to this control of energy balance, e.g. leading to obesity, potentially through a mismatch between the expected pleasure compared to the actual energy uptake from food intake [11,45].
Motivation-independent processing of identity and intensity
It is vital that reliable sensory food information is provided for the brain to guide ingestion decision-making. Eating has to be controlled very carefully since erroneous evaluation of the sensory properties of foods can potentially be fatal if ingesting toxins, microorganisms or non-food objects. Mammals have been shown to have brainstem reflexes (stereotypical for each basic taste) that are based on rudimentary analyses of the chemical composition, and which are not altered, even by the loss of all neural tissue above the level of the midbrain . Eating-related behaviours in humans and other animals can usefully be described as a strategy to maintain a balance between conservative risk-minimising and life-preserving strategies (exploitation) with occasional novelty seeking (exploration) in the hope of discovering new, valuable sources of nutrients .
Learning-dependent multisensory representations
Food-related decision-making depends on the integration of multisensory information about the food which includes information about temperature, viscosity, texture, fat contents, pungency and irritation mediated by a large variety of neural systems . Neuroimaging this learning-dependent multisensory integration has found that the human orbitofrontal cortex integrates information from auditory , gustatory , olfactory , somatosensory  and visual  inputs, as well as information from the visceral sensory system . The role of expectation and motivational control of appetite has also been investigated using restaurant menus which also found engagement of the orbitofrontal cortex  .
These human findings are consistent with neurophysiological recordings showing that the non-human primate orbitofrontal cortex receives input from all of the five senses . These sensory inputs enter the orbitofrontal cortex primarily through its posterior parts and are integrated in more anterior areas . The interaction between taste and smell revealed by neuroimaging is found in the orbitofrontal cortex and nearby agranular insula (Figure 4C) [33,50,63].
Reward representations of sensory stimuli
These reward-related findings in the medial OFC cohere with neuroimaging studies using other rewards. One study found a correlation between activity in the medial OFC with the amount of monetary wins and losses  (Figure 5B). Similarly, the subjective experience of methamphetamine over minutes was found to correlate with activity in the medial OFC  (Figure 5C). Even studies on the much shorter timescales of milliseconds have found activity in the medial OFC related to the reward of images of cute babies  (Figure 5D). These results point to the unity of reward-related activity in the pleasure system across many different rewards, which in turn suggest a system with a common currency of reward. Such a system would make it easier to decide and choose between different rewards.
Representations of hedonic experience
Finally, the evidence suggests that the subjective hedonic experience of food is encoded in activity in the pleasure system. In humans, the mid-anterior orbitofrontal cortex (mid-OFC) appears to be a key region as demonstrated by a selective-satiety neuroimaging study where activity in this region shows not only a selective decrease in the reward value to the food eaten to satiety (and not to the food not eaten) but also a correlation with pleasantness ratings (Figure 5E) . This result indicates that the reward value of the taste, olfactory and somatosensory components of a food are represented in the orbitofrontal cortex and, therefore, that the subjective pleasantness of food might be represented in this region. Other studies have supported this finding, including an experiment investigating true taste synergism, where the intensity of a taste is dramatically enhanced by adding minute doses of another taste. The strong subjective enhancement of the pleasantness of umami taste that occurs when 0.005 M inosine 5′-monophosphate is added to 0.5 M monosodium glutamate (compared to both delivered separately) correlated with increased activity in mid-OFC (Figure 5 F) . Similarly, investigations of the synergistic enhancement of a matched taste and retronasal smell found significant activity in the same mid-OFC region (Figure 5G) . These food-related hedonic findings fit well with evidence coming from the study of other pleasures, including the finding of significant activity in mid-OFC in a study using magnetoencephalography (MEG) with deep brain stimulation to investigate the pleasurable relief from severe chronic pain (Figure 5H) .
As demonstrated poignantly by Babette’s Feast, food is not only an important part of a balanced diet; it is also one of our main routes to pleasure. The novella opens many interesting question with regard to well-being and the good life and in particular shows that to allow oneself to be open to the possibility of pleasure of food is also allowing for the deep experiences of the multitude of pleasures. This is in sharp contrast to the denial of the pleasure of food leading to anhedonia, the lack of pleasure, which is a key constituent component of affective disorders.
The science of pleasure has made great strides in recent years , due not in small parts to using food as a pleasure-eliciting stimulus. As demonstrated in this review, the research has uncovered many of the fundamental brain mechanisms governing eating and pleasure in general. It has helped understand the brain’s complex resource allocation problems with food competing with other rewards for time and resources. In particular, the brain must make important decisions of how best to balance exploration and exploitation to ensure survival. These decisions involve deciding when to pursue a reward, and whether to initiate, sustain and terminate the wanting, liking and learning processes involved in the different phases of the pleasure cycle (Figure 1). Eating is a complex process that involves many different factors over time as described in a multilevel model (Figure 2). The model demonstrates the cyclical changes in hunger levels related to the initiation and termination of meals, as they relate to signals from the brain, gut-brain, oral cavity, stomach and intestines, liver and metabolites and body mass.
Furthermore, pleasure research has shown that food, sex and social interactions are fundamental to our survival and these basic stimuli take priority in resource allocation. It has also shown the unity of pleasure processing of different rewards, with food, sex, social and higher-order stimuli (such as music and money) in a unified pleasure system [12,13,74-76,84].
Much remains to be done, but finally science has gained a toehold in understanding how pleasure can come to transform lives. Understanding the pleasure of food has played a major part in hedonia research and may even offer some insights into well-being. We have previously taken a lead from Aristotle’s distinction between hedonia and eudaimonia (a life well-lived) to show how the study of pleasure may offer some insights into well-being .
Gastronomy offers the potential to expand on these findings and create exciting experiences and great pleasure. The rise of molecular gastronomy and gastrophysics have afforded chefs with unprecedented control over the production of novel flavours and textures of food [78,79]. These experiences are by their very nature multisensory and like all experiences highly dependent on expectation and prior experiences . Using scientific tools and insights allows playful chefs to create unique and highly pleasurable dining experiences, e.g. using touch and sound as interesting extras in their gastronomical palette . Yet, all foods are ultimately dependent on the state of the diner’s brain and body , and the emergence of the neuroscience of the pleasure of gastronomy could help guide further progress [11,83]. Both the science and art of cooking stand to benefit much from future collaborations between scientists and chefs, especially in so far this research can help increase the pleasure of eating and well-being.
Babette’s Feast shows how a sumptuous dinner can bring about much pleasure and transform lives. Babette uses all her money and skills on creating the once-in-a-lifetime dinner, yet at the end she tells the sisters: “A great artist, Mesdames, is never poor. We have something, Mesdames, of which other people know nothing”. While it is true that creating great art takes skills and years of practice, it is also important to remember that every moment and every bite of food carries within it the possibility of pleasure. The brain is built for pleasure and it is through learning to appreciate the extraordinary in ordinary experiences, through pursuing the variety of pleasures rather than the relentless single-minded pursuit (hedonism) or denial of pleasure (asceticism) that a life well-lived can be constructed.
This research is supported by the TrygFonden Charitable Foundation.
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