A genetic variant near olfactory receptor genes influences cilantro preference

Table 2 Index SNPs for regions with p < 10 ⁻⁶ for cilantro soapy-taste

SNP	Chromosome	Position	Gene	Allele	MAF	r ²	p _discovery	p _repl	OR (CI)	Chromosome
rs72921001	11	6,889,648	OR6A2	C/A	0.364	0.969	6.4×10⁻⁹	0.0057	0.809 (0.753–0.870)	Chromosome
rs78503206	6	158,311,499	SNX9	C/T	0.077	0.980	3.2×10⁻⁸	0.49	0.679 (0.588–0.784)	Chromosome
chr5:4883483	5	4,883,483	ADAMTS16	C/T	0.032	0.885	1.7×10⁻⁷	0.51	0.526 (0.405–0.683)	Chromosome
rs7227945	18	4,251,279	DLGAP1/LOC642597	T/G	0.055	0.920	5.3×10⁻⁷	0.96	1.447 (1.258–1.663)	Chromosome
rs6554267	4	56,158,891	KDR/SRD5A3	T/G	0.019	0.651	7.4×10⁻⁷	0.85	1.975 (1.529–2.549)	Chromosome
rs13412810	2	192,420,461	MYO1B/OBFC2A	G/A	0.141	0.942	7.9×10⁻⁷	0.78	0.770 (0.693–0.857)	Chromosome

The index SNP is defined as the SNP with the smallest p value within a region. The listed gene is our postulated candidate gene near the SNP. Alleles are listed as major/minor (in Europeans). MAF is the frequency of the minor allele in Europeans, and r² is the estimated imputation accuracy. p_discovery and p_repl are the discovery and replication p values, respectively. The OR is the discovery odds ratio per copy of the minor allele (e.g., the A allele of rs72921001 is the allele associated with a lower risk of detecting a soapy taste).

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