The name of deliciousness and the gastrophysics behind it
© Mouritsen et al.; licensee BioMed Central Ltd. 2013
Received: 8 November 2012
Accepted: 8 November 2012
Published: 9 January 2013
The term ‘gastrophysics’ has been proposed to describe an emerging scientific discipline that employs an arsenal of the most powerful theoretical, simulational, and experimental techniques from the physical sciences to study the empirical world of cooking and gastronomy. In the same way that biology has inspired the field of biophysics, gastronomy is the source of inspiration for gastrophysics. In particular, gastrophysics aims at exploiting recent advances in the physical sciences to forward the scientific study of food, the raw materials used, the effects of processing food, and quantitative aspects of the physical basis for food quality, flavor, appreciation, and absorption in the human body. In this study, we focused on questions pertaining to the texture and flavor of a particular type of raw material, namely, the red seaweed, dulse (Palmaria palmata), and demonstrate how a combination of physical chemistry, biophotonics, and atomic-scale molecular simulation might shed some light on these questions, particularly in relation to the physical mechanism of the umami sensation.
KeywordsGastrophysics Umami Seaweeds Receptor Synergy
Gastrophysics research program
Ole Mouritsen and Jens Risbo
We and our colleagues at the Center for Biomembrane Physics have a wide range of interests, competencies, and facilities in the broad field of biophysics, and in the physics and physical chemistry of biological materials. In particular, we are interested in lipids, proteins, and membranes, as well as of the different phenomena related to membranes, including membrane function, the action of drugs, and the effects of various processes on membranes. Moreover, we have available a large arsenal of theoretical, experimental, and simulational methods and instrumentation. Taken together with a keen interest in food and the enjoyment of food, a natural step was to apply all these capacities to study problems related to gastronomy. After all, the empirical world of cooking mostly uses materials of biological origin, the methods used in cooking involve some kind of chemical and physical processing [1–5], and the sensations of food, such as mouth-feel and flavor, are based on mechanisms obeying principles from physics and chemistry.
An initial interest in food from the sea, stimulated by the first author’s passion for Japanese cuisine, particularly sushi , gradually developed into questions regarding the use of marine macroalgae (seaweeds) , and from there to the flavor of certain seaweeds, in particular the taste of deliciousness (umami) [8, 9]. The work was greatly stimulated by collaboration with a range of inventive chefs.
We provide a brief preliminary report on the likely results to which such an approach can lead, and hence, by example, give an opinion on what gastrophysics could be.
Flavor of seaweeds
The history of flavor owes so much to a discovery made by Kikunae Ikeda, who in 1908  studied the chemical composition of the large brown seaweed, konbu (Saccharina japonica). Konbu is used together with a highly processed fish product, katsuobushi, to produce dashi, the soup broth around which the entire Japanese cuisine revolves. Ikeda found that konbu contains very large amounts of free monosodium L-glutamate (MSG). He suggested that this compound is the primordial source, or the essence of deliciousness (umami), and he proposed it as a fifth basic taste quality, in addition to the existing four qualities of salt, sour, sweet, and bitter. However, it was only in the early part of this century, after the discovery of specific umami receptors located in the taste-cell membranes, that umami was fully recognized as a basic physiological taste sense [11–15].
Texture of seaweeds
Seaweeds also play another important, but little-known role in cooking. Their contents of certain complex polysaccharides particularly alginate, agar, and carrageenan, readily form stable hydrogels and are highly valued as gelling agents, providing texture to foodstuffs and enhancing the mouth-feel of fluid materials. These polysaccharides are used by the seaweeds to bind together their cells that in most species are little specialized. The polysaccharides can be extracted from the seaweeds by chemical methods, thus alginate, agar, and carrageenan introduced into foodstuff have to be declared as food additives.
The molecular mechanism of the umami receptor
Our work on the flavor of seaweeds led to questions regarding the molecular mechanism of the umami sensation, particularly the special synergy that pertains to the simultaneous presence of glutamate and certain 5′-ribonucleotides. The unique aspect of the umami taste is that it can be enhanced many times by the presence of free nucleotides such as inosine 5′-monophosphate (IMP), guanosine 5′-monophosphate (GMP), and adenosine 5′-monophosphate (AMP). Free glutamate is found in large amounts in cured hams, anchovy paste, ripe tomatoes, walnuts, hard and mature cheeses, and soy and fish sauces, as well as certain brown seaweeds. Free nucleotides are abundant in meat broths, chicken, fish and shellfish, mollusks, and dried fungi. In the classical Japanese dashi, the seaweeds provide free glutamate and the katsuobushi free IMP. In shojin ryori, the vegan Japanese temple cuisine, the fish is replaced by shiitake mushrooms, which contain large amounts of free GMP [18–20].
A deeper understanding of this remarkable synergy in umami sensation requires insight into the structure and functioning of the umami receptors that reside in the taste-cell membranes . Although three different kinds of umami receptors have been discovered since 2000, one particular heterodimer G-protein coupled receptor, T1R1/T1R3, is most likely to hold the key to the synergy in umami.
Conclusion and future outlook
We consider that gastrophysics has as its goal to demonstrate that fundamental principles of physics, in particular soft-matter physics, biophysical chemistry, and molecular biophysics, can be brought together to work within the sciences dealing with food. In this paper, we give examples of how questions stimulated by an interest in gastronomy can lead to new insights that both have scientific merit in themselves and can have an influence on gastronomy.
For this study, we focused attention on a little-explored material in the context of gastronomy, namely seaweed , and found that this material has very interesting flavor and texture properties. Moreover, using a detailed and well-defined molecular model, our molecular simulations have established, quantitative support for the proposed and putative mechanism  behind the ubiquitous synergy effect in the umami sensation. The power of this synergy for cooking delicious food has been known and used by cooks for centuries, and in 1960, it was shown that inosinate from fermented fish or guanylate from dried shiitake together with glutamate from dried seaweeds provided enhanced umami flavor in soup broths . In this study, we have revealed that this exciting mechanism arises as a consequence of an allosteric molecular action at the receptor.
The findings of our gastrophysical research program on seaweeds and umami holds promise for the design of novel compounds to controlling the umami flavoring of foodstuffs. Furthermore, our findings regarding the mechanism of the umami taste at the receptor level may not only lead to inspiration for new delicious dishes but may indicate how best to use umami as a means to regulate food intake and to improve nutrition and health .
MEMPHYS is supported as a center of excellence by the Danish National Research. HK is funded by a Lundbeck Junior Group Leader Fellowship. The computations were performed at the Danish Center for Scientific Computing at the University of Southern Denmark.
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