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Correlated glomerular convergence and latency coding of odors in mitral cells

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Behavioral responses to olfactory stimuli can happen after less than half a second after stimulus arrival. Given ORN spike rates in the order of 0 to 15 spikes/s it appears unlikely that average spike rates play a major role for the detection of the odor and the bahavioral response to it. We therefore assumed the other extreme, i.e. that the first spike of an odor response of a mitral cells is important for detection and quality coding (which does not exclude other effects). Using activity contrast imaging (ACI, [1]) we could indeed show that the response latency vectors code odor quality with high fidelity [2] in virtually synchronous ensembles of mitral cells [3]. We hypothesize that the first spike of a mitral cell is somehow induced by correlated glomerular input. This view is strengthened by the existence of bifurcations in ORN axons so far seen in Xenopus [4] and mice [5]. Such bifurcations obviously lead to hardwired correlations in an ontogenetical situation where, due to a relatively low number of axons, stimulus-induced, correlated ORN activities are sparse or absent.

References

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    Junek S, Chen T-W, Alevra M, Schild D: Activity correlation imaging: visualizing function and structure of neuronal populations. Biophys J. 2009, 96: 3801-3809.

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    Junek S, Kludt E, Wolf F, Schild D: Olfactory coding with patterns of response latencies. Neuron. 2010, 67: 872-884.

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    Chen T-W, Lin B-J, Schild D: Odor coding by modules of coherent mitral/tufted cells in the vertebrate olfactory bulb. Proc Natl Acad Sci U S A. 2009, 106: 2401-2406.

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    Nezlin LP, Schild D: Individual olfactory sensory neurons project into more than one glomerulus in Xenopus laevis tadpole olfactory bulb. J Comp Neurol. 2005, 481: 233-239.

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    Marcucci F, Maier-Balough E, Zou D-J, Firestein S: Exuberant growth and synapse formation of olfactory sensory neuron axonal arborizations. J Comp Neurol. 2011, 519: 3713-3726.

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Correspondence to Detlev Schild.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schild, D. Correlated glomerular convergence and latency coding of odors in mitral cells. Flavour 3, O12 (2014) doi:10.1186/2044-7248-3-S1-O12

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Keywords

  • Behavioral Response
  • Response Latency
  • Contrast Imaging
  • Psychology Research
  • Latency Vector