Correlated glomerular convergence and latency coding of odors in mitral cells
Flavour volume 3, Article number: O12 (2014)
Behavioral responses to olfactory stimuli can happen after less than half a second after stimulus arrival. Given ORN spike rates in the order of 0 to 15 spikes/s it appears unlikely that average spike rates play a major role for the detection of the odor and the bahavioral response to it. We therefore assumed the other extreme, i.e. that the first spike of an odor response of a mitral cells is important for detection and quality coding (which does not exclude other effects). Using activity contrast imaging (ACI, ) we could indeed show that the response latency vectors code odor quality with high fidelity  in virtually synchronous ensembles of mitral cells . We hypothesize that the first spike of a mitral cell is somehow induced by correlated glomerular input. This view is strengthened by the existence of bifurcations in ORN axons so far seen in Xenopus  and mice . Such bifurcations obviously lead to hardwired correlations in an ontogenetical situation where, due to a relatively low number of axons, stimulus-induced, correlated ORN activities are sparse or absent.
Junek S, Chen T-W, Alevra M, Schild D: Activity correlation imaging: visualizing function and structure of neuronal populations. Biophys J. 2009, 96: 3801-3809.
Junek S, Kludt E, Wolf F, Schild D: Olfactory coding with patterns of response latencies. Neuron. 2010, 67: 872-884.
Chen T-W, Lin B-J, Schild D: Odor coding by modules of coherent mitral/tufted cells in the vertebrate olfactory bulb. Proc Natl Acad Sci U S A. 2009, 106: 2401-2406.
Nezlin LP, Schild D: Individual olfactory sensory neurons project into more than one glomerulus in Xenopus laevis tadpole olfactory bulb. J Comp Neurol. 2005, 481: 233-239.
Marcucci F, Maier-Balough E, Zou D-J, Firestein S: Exuberant growth and synapse formation of olfactory sensory neuron axonal arborizations. J Comp Neurol. 2011, 519: 3713-3726.
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Schild, D. Correlated glomerular convergence and latency coding of odors in mitral cells. Flavour 3 (Suppl 1), O12 (2014). https://doi.org/10.1186/2044-7248-3-S1-O12